Intercostal muscle pacing with high frequency spinal cord stimulation in dogs.
Intercostal muscle pacing with high frequency spinal cord stimulation in dogs.
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DOI：
10.1016/j.resp.2010.03.017
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发表时间：
2010-05-31
影响因子：
2.3
通讯作者：
Kowalski, Krzysztof E.
中科院分区：
文献类型：
--
作者：
DiMarco, Anthony F.;Kowalski, Krzysztof E.
High frequency spinal cord stimulation (HF-SCS) is a novel and more physiologic method of inspiratory muscle activation which involves stimulation of spinal cord pathways. In the present study, we determined if activation of the inspiratory intercostal muscles alone by this technique could be utilized to maintain artificial ventilation. In 7 anesthetized dogs, following C2 spinal cord section and bilateral phrenicotomy, trains of electrical stimulation (12 times/min) were applied at the T2 level. Eucapnea was maintained during an initial 5.5 hour period of continuous stimulation. During a subsequent 0.5 hour period, stimulus parameters were increased to induce hyperventilation resulting in a sustained fall in end-tidal PCO2 to 29.3 ± 0.4 mmHg. Single motor unit peak firing frequencies of the intercostal muscles during HF-SCS were similar to those occurring during spontaneous breathing. This technique holds promise as a method to restore ventilation in ventilator-dependent tetraplegics who do not have adequate phrenic nerve function for diaphragm pacing.
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影响因子：
4.1
作者：
CIESIELSKI, TE;FUKUDA, Y;HOGAN, JF
通讯作者：
HOGAN, JF
影响因子：
3.3
作者：
DiMarco, AF;Connors, AF;Kowalski, KE
通讯作者：
Kowalski, KE
影响因子：
3.3
作者：
DiMarco, AF;Romaniuk, JR;Supinski, G
通讯作者：
Supinski, G
DOI：
10.1111/j.1540-8159.1986.tb06627.x
发表时间：
1986-11-01
影响因子：
1.8
作者：
GLENN, WWL;PHELPS, ML;HOGAN, JF
通讯作者：
HOGAN, JF
影响因子：
2.3
作者：
DiMarco, AF
通讯作者：
DiMarco, AF