Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1.
Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1.
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发表时间：
1988
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通讯作者：
T. Doi;L. Striker;C. Quaife;F. Conti;R. Palmiter;R. Behringer;R. Brinster;G. Striker
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作者：
T. Doi;L. Striker;C. Quaife;F. Conti;R. Palmiter;R. Behringer;R. Brinster;G. Striker
肾次全切除和糖尿病等疾病状态下，肾小球大小在正常成熟时增大。生长激素(GH)、生长激素释放因子(GHRF)和胰岛素样生长因子-1(IGF-1)在这些过程中所起的作用已经在长期表达这些激素的转基因小鼠中进行了研究。3个品系的小鼠肾小球均增大。系膜增生和进行性肾小球硬化仅在GH和GHRF动物中观察到。在IGF-1组小鼠中，大的肾小球除了增大外，形态上保持正常。这些数据表明，肾小球硬化的部分原因是肾小球系膜细胞对循环生长激素的反应紊乱。慢性血浆生长激素水平高的小鼠的系膜病变与人类糖尿病的病变相似。这些模型为研究激素对肾小球生长的调节以及特定激素在肾小球硬化发病机制中可能发挥的作用提供了一种手段。
An increase in glomerular size occurs in normal maturation after subtotal renal ablation and disease states such as diabetes mellitus. The role that growth hormone (GH), growth hormone releasing factor (GHRF), and insulinlike growth factor-1 (IGF-1) play in these processes has been investigated using transgenic mice chronically expressing these hormones. The glomeruli were enlarged in all 3 strains of mice. Mesangial proliferation followed by progressive glomerulosclerosis was observed in the GH and GHRF animals only. In the IGF-1 mice the large glomeruli remained morphologically normal except for the enlargement. These data suggest that the glomerulosclerosis was due, in part, to disordered mesangial cell growth in response to circulating GH. The mesangial lesions in mice with chronically high plasma GH levels mimicked those in human diabetes mellitus. These models provide a means to study the hormonal regulation of glomerular growth and the role that specific hormones might play in the pathogenesis of glomerulosclerosis.