INTERACTION OF NOREPINEPHRINE WITH CEREBROCORTICAL ACTIVITY EVOKED BY STIMULATION OF SOMATOSENSORY AFFERENT PATHWAYS IN THE RAT
INTERACTION OF NOREPINEPHRINE WITH CEREBROCORTICAL ACTIVITY EVOKED BY STIMULATION OF SOMATOSENSORY AFFERENT PATHWAYS IN THE RAT
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DOI：
10.1016/0014-4886(80)90159-4
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发表时间：
1980-01-01
影响因子：
5.3
通讯作者：
WOODWARD, DJ
中科院分区：
文献类型：
--
作者：
WATERHOUSE, BD;WOODWARD, DJ
研究了去甲肾上腺素（NE）对体感皮质神经元回路信息传输的作用。在大鼠体感皮层（S1）的前肢区域，在微离子导入应用 NE 之前、期间和之后记录对传入通路自然刺激（足部轻拍）的单单位反应。通过基于计算机的刺激后时间直方图分析来定量评估 NE 的作用。总体而言，NE 增强了传入突触输入产生的兴奋性和抑制性反应。在 78% 的测试细胞中，低剂量的 NE 对背景放电的抑制程度高于刺激结合激发，从而使信噪比增强约 2 倍。在 NE 给药期间，12 个细胞中诱发的尖峰定量增加至高于对照值。在 82% 的检查单位中，NE 增强了刺激结合抑制和兴奋后活动抑制。在 NE 剂量下，在 5 个细胞中观察到抑制增强，这很少或不引起自发活动的抑制。这些观察到的对神经元对传入突触输入的反应性的影响通常在 NE 离子电渗疗法终止后持续几分钟。 NE 的这种调节作用已在位于皮层垂直范围内的细胞中得到证实。少量的 NE 可能有助于大脑皮层回路内传入信息的传递，并且与 NE 的调节作用而不是特定的传递功能一致。
The action of norepinephrine (NE) on transmission of information through somatosensory cortical neuronal circuits was investigated. In the forelimb region of rat somatosensory cortex (S1), single-unit responses to natural stimulation (foot tap) of afferent pathways were recorded before, during and after microiontophoretic application of NE. Actions of NE were quantitatively assessed by computer-based analysis of poststimulus time histograms. Overall, NE enhanced both excitatory and inhibitory responses generated by the afferent synaptic input. In 78% of the cells tested, low doses of NE differentially suppressed background discharge more than stimulus-bound excitation such that the signal to noise ratio was enhanced about 2-fold. Evoked spiking in 12 cells was quantitatively increased above control values during NE administration. In 82% of the units examined, NE augmented stimulus-bound inhibition and postexcitatory suppression of activity. Potentiation of inhibition was observed in 5-cells at doses of NE which caused little or no depression of spontaneous activity. These observed effects on neuronal responsiveness to afferent synaptic input often persisted for several minutes after termination of NE iontophoresis. Such modulatory actions of NE were demonstrated for cells situated throughout the vertical extent of the cortex. Low amounts of NE may facilitate transfer of afferent information within the cerebral cortical circuitry and are consistent with a modulatory role rather than a specific transfer function for NE.