Evaluation of psychosomatic stress in children by measuring salivary chromogranin A
Evaluation of psychosomatic stress in children by measuring salivary chromogranin A
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DOI：
10.1080/08035250500538940
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发表时间：
2006-08-01
期刊：
影响因子：
3.8
通讯作者：
Nagasawa, Shingo
中科院分区：
文献类型：
--
作者：
Lee, Tsubasa;Shimizu, Toshiaki;Nagasawa, Shingo
目的：探讨儿童唾液嗜铬粒蛋白A （CgA）和皮质醇作为应激标志物的作用及分心对应激抑制的影响。方法：我们使用万花筒检测住院儿童静脉穿刺前后唾液CgA和皮质醇的反应。结果：静脉穿刺后即刻唾液CgA水平显著高于穿刺前；静脉穿刺后60min唾液CgA水平显著低于穿刺后即刻。然而，唾液皮质醇在三个时间点上均无显著差异。相比之下，被万花筒分散注意力时，在所有三个时间点唾液CgA和皮质醇水平均无显著差异。
Aim: To investigate the usefulness of salivary chromogranin A (CgA) and cortisol as stress markers, and the effects of distraction on the suppression of stress in children. Methods: We examined salivary CgA and cortisol responses before and after venipuncture in hospitalized children with and without distraction using a kaleidoscope. Results: Salivary CgA levels immediately after venipuncture were significantly higher than those immediately before it, and at 60 min after venipuncture they were significantly lower than those immediately after it. However, salivary cortisol showed no significant differences at any of the three time points. In contrast, distracted by the kaleidoscope, there were no significant differences in salivary CgA and cortisol levels at all three time points.