Matching on-the-fly: Sequential allocation with higher power and efficiency
Matching on-the-fly: Sequential allocation with higher power and efficiency
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DOI：
10.1111/biom.12148
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发表时间：
2014-06-01
期刊：
影响因子：
1.9
通讯作者：
Krieger, Abba
中科院分区：
文献类型：
--
作者：
Kapelner, Adam;Krieger, Abba
我们提出了一种动态分配程序，该程序在测量固定样本随机试验的平均治疗效果时增加了功率和效率。受试者迭代到达，随机或通过匹配标准与先前随机受试者配对，并进行替代治疗。我们开发了平均治疗效果的估计值，该估计值结合了来自匹配配对和不匹配受试者的信息以及精确测试。仿真和临床试验数据表明，该方法比几种竞争分配方法具有更高的效率和能力。
We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in fixed sample randomized trials with sequential allocation. Subjects arrive iteratively and are either randomized or paired via a matching criterion to a previously randomized subject and administered the alternate treatment. We develop estimators for the average treatment effect that combine information from both the matched pairs and unmatched subjects as well as an exact test. Simulations illustrate the method's higher efficiency and power over several competing allocation procedures in both simulations and in data from a clinical trial.