Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy
Miyabeacin: A new cyclodimer presents a potential role for willow in cancer therapy
复制标题
DOI：
10.1038/s41598-020-63349-1
复制
发表时间：
2020-04
影响因子：
4.6
通讯作者：
J. Ward;Yanqi Wu;Claudia Harflett;Hannah Onafuye;D. Corol;Charlotte Lomax;W. Macalpine;J. Cinatl;Mark N. Wass;M. Michaelis;M. H. Beale
中科院分区：
文献类型：
--
作者：
J. Ward;Yanqi Wu;Claudia Harflett;Hannah Onafuye;D. Corol;Charlotte Lomax;W. Macalpine;J. Cinatl;Mark N. Wass;M. Michaelis;M. H. Beale
杨柳（Salix spp.）作为药用化合物的来源是众所周知的，最著名的是水杨苷，阿司匹林的前身。本文描述了从S. miyabeanaandS.毛枝藻我们还表明，产生这种二聚体的能力是一种遗传性状，以及天然miyabeacin类似物的结构变化是如何从ofortho-quinol前体中通过交叉Diels-Alder反应衍生出来的。这些短暂的邻-喹啉类化合物在水杨科汀周围的生物合成途径中发挥作用，水杨科汀是许多杨柳基因型的主要水杨酸。
Willow(Salix spp.)is well known as a source of medicinal compounds, the most famous being salicin, the progenitor of aspirin. Here we describe the isolation, structure determination, and anti-cancer activity of a cyclodimeric salicinoid (miyabeacin) fromS. miyabeanaandS. dasyclados. We also show that the capability to produce such dimers is a heritable trait and how variation in structures of natural miyabeacin analogues is derivedviacross-over Diels-Alder reactions from pools ofortho-quinol precursors. These transientortho-quinols have a role in the, as yet uncharacterised, biosynthetic pathways around salicortin, the major salicinoid of many willow genotypes.