NF-κB, inflammation, and metabolic disease.
NF-κB, inflammation, and metabolic disease.
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DOI：
10.1016/j.cmet.2010.12.008
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发表时间：
2011-01-05
期刊：
影响因子：
29
通讯作者：
Ghosh S
中科院分区：
文献类型：
--
作者：
Baker RG;Hayden MS;Ghosh S
包括肥胖症、2型糖尿病和动脉粥样硬化在内的代谢性疾病历来被认为是营养过剩引起的脂质储存障碍。现在广泛认识到慢性低度炎症在代谢性疾病的起始、传播和发展中起关键作用。与其在协调炎症反应中的中心作用一致，许多最近的研究表明转录因子NF-κB参与了这些疾病的发展，从而进一步确立了炎症作为其病因学中的关键因素，并为开发新的治疗方法提供了希望。
Metabolic disorders including obesity, type 2 diabetes and atherosclerosis have been viewed historically as lipid storage disorders brought about by overnutrition. It is now widely appreciated that chronic low-grade inflammation plays a key role in the initiation, propagation and development of metabolic diseases. Consistent with its central role in coordinating inflammatory responses, numerous recent studies have implicated the transcription factor NF-κB in the development of such diseases, thereby further establishing inflammation as a critical factor in their etiology and offering hope for the development of new therapeutic approaches for their treatment.
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