The roles of human viruses in the pathogenesis of lymphoma.
The roles of human viruses in the pathogenesis of lymphoma.
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人类病毒在淋巴瘤发病机制中的作用。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
Liebowitz Dn
中科院分区：
文献类型：
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作者：
Lyons Sf;Liebowitz Dn
有两个病毒家族会导致人类淋巴瘤发生：疱疹病毒和逆转录病毒。这两种疱疹病毒是 Epstein-Barr 病毒 (EBV) 和人类疱疹病毒 8 (HHV-8)。 EBV 是一种特性非常明确的转化剂：九种病毒蛋白有助于体外转化。相反，在体内，EBV基因表达模式随不同类型的恶性肿瘤而变化。 EBV 与地方性伯基特淋巴瘤、获得性免疫缺陷综合征 (AIDS) 相关淋巴瘤、移植后淋巴组织增生性疾病、霍奇金病 (HD) 和罕见 T 细胞淋巴瘤有关。我们总结了不同 EBV 相关恶性肿瘤中病毒基因表达和信号转导的不同模式的研究，这些研究已开始揭示 EBV 如何对不同疾病的恶性表型做出不同的贡献。 HHV-8 与艾滋病患者的原发性渗出性淋巴瘤相关，我们总结了有关该病毒的快速积累的信息。人类 T 细胞白血病病毒 1 (HTLV-1) 是一种逆转录病毒，是成人 T 细胞白血病/淋巴瘤 (ATL) 的病原体。 HTLV-1介导的T细胞转化的具体机制尚不清楚，但综述了HTLV-1对白细胞介素2信号传导的影响。
There are two families of viruses that contribute to lymphomagenesis in humans: herpesviruses and retroviruses. The two herpesviruses are the Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8). EBV is an extremely well-characterized transforming agent: nine viral proteins contribute to transformation in vitro. In contrast, in vivo, the pattern of EBV gene expression varies with different types of malignancies. EBV is associated with endemic Burkitt's lymphoma, acquired immune deficiency syndrome (AIDS)-related lymphoma, post-transplantation lymphoproliferative disease, Hodgkin's disease (HD), and rare T-cell lymphomas. We have summarized studies on the different patterns of viral gene expression and signaling in different EBV-related malignancies, which have begun to reveal how EBV variably contributes to the malignant phenotype in different diseases. HHV-8 is associated with primary effusion lymphomas in patients with AIDS, and the rapidly accumulating information on this virus is summarized. Human T-cell leukemia virus-1 (HTLV-1) is a retrovirus which is the causative agent of adult T-cell leukemia/lymphoma (ATL). The specific mechanism of HTLV-1-mediated T-cell transformation is unclear, but the effects of HTLV-1 on interleukin-2 signaling are reviewed.