The effect of zidovudine on neuropsychiatric measures in HIV-infected men.
The effect of zidovudine on neuropsychiatric measures in HIV-infected men.
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齐多夫定对艾滋病毒感染男性神经精神指标的影响。
DOI：
10.1176/ajp.150.3.505
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Ehrhardt,AA
中科院分区：
文献类型：
--
作者：
Gorman,JM;Mayeux,R;Stern,Y;Williams,JB;Rabkin,J;Goetz,RR;Ehrhardt,AA
作者在相隔6个月的三个评估点上，在25名服用齐多夫定至少6个月的HIV阳性男性和25名从未服用过齐多夫定的HIV阳性男性中，研究了齐多夫定对神经精神病学措施的影响。齐多夫定除了在全球功能评定量表评分上略有改善外，在统计学上没有显著影响。在这一小群受试者中，齐多夫定对中枢神经系统的毒性几乎没有好处，也几乎没有证据。
The authors examined the effects of zidovudine on neuropsychiatric measures, at three assessment points separated by 6 months, in 25 HIV-positive men who took zidovudine for at least 6 months and a comparison group of 25 HIV-positive men with similar CD4+ T cell counts who had never taken zidovudine. Zidovudine had no statistically significant effect except for a slight improvement in Global Assessment of Functioning scale score. In this small group of subjects there was little benefit but also little evidence of CNS toxicity from zidovudine.