Mammalian sugar‐binding receptors: known functions and unexplored roles
Mammalian sugar‐binding receptors: known functions and unexplored roles
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DOI：
10.1111/febs.14759
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发表时间：
2019-02
期刊：
影响因子：
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通讯作者：
Maureen E. Taylor;K. Drickamer
中科院分区：
文献类型：
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作者：
Maureen E. Taylor;K. Drickamer
哺乳动物聚糖结合受体，有时称为凝集素，与聚糖、内源哺乳动物糖蛋白和糖脂的寡糖部分以及微生物表面的糖相互作用。这些受体引导糖蛋白进出细胞，通过粘附和信号传导促进细胞之间的通讯，并使先天免疫系统能够对病毒、真菌、细菌和寄生虫病原体快速做出反应。对于人类已知的大约 100 种聚糖结合受体中的许多受体，对于它们结合的聚糖类型以及如何在分子水平上实现对这些配体的选择性有很好的描述。在某些情况下，还有全面的证据证明受体在细胞和有机体水平上发挥的作用。除了强调这些众所周知的聚糖结合受体范例之外，这篇综述还将指出我们对它们所发挥的生理功能的理解中仍然存在差距。
Mammalian glycan‐binding receptors, sometimes known as lectins, interact with glycans, the oligosaccharide portions of endogenous mammalian glycoproteins and glycolipids as well as sugars on the surfaces of microbes. These receptors guide glycoproteins out of and back into cells, facilitate communication between cells through both adhesion and signaling, and allow the innate immune system to respond quickly to viral, fungal, bacterial, and parasitic pathogens. For many of the roughly 100 glycan‐binding receptors that are known in humans, there are good descriptions of what types of glycans they bind and how selectivity for these ligands is achieved at the molecular level. In some cases, there is also comprehensive evidence for the roles that the receptors play at the cellular and organismal levels. In addition to highlighting these well‐understood paradigms for glycan‐binding receptors, this review will suggest where gaps remain in our understanding of the physiological functions that they can serve.