Periodontal tissue engineering by growth factors
Periodontal tissue engineering by growth factors
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DOI：
10.1016/s8756-3282(96)00127-5
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发表时间：
1996-07-01
期刊：
影响因子：
4.1
通讯作者：
Giannobile, WV
中科院分区：
文献类型：
--
作者：
Giannobile, WV
多肽生长因子（GF）已被证明可以调节硬组织和软组织的伤口愈合反应。在过去的十年中，许多研究人员已经证明了这些伤口愈合分子对促进牙周附着结构，即牙槽骨，牙周韧带和牙根牙骨质的合成代谢作用。GFs的分子克隆和大规模纯化使得牙周组织再生的体内研究得以扩展。本文将概述这些因素在体外和体内水平上对促进牙周和种植体周围骨伤口愈合的具体影响，本文将总结未来的前景，在人类临床试验竞技场使用生长和骨诱导因子，以促进牙周组织再生和牙槽骨修复在口腔中正在进行的研究。
Polypeptide growth factors (GFs) have been shown to modulate the wound healing response in both hard and soft tissues. During the past decade, many investigators have demonstrated the anabolic effects of these wound healing molecules on the promotion of periodontal attachment structures, namely alveolar bone, periodontal ligament and tooth root cementum. The molecular cloning and large scale purification of GFs has allowed expanded in vivo studies on periodontal tissue regeneration. This review will outline specific effects of these factors at both the in vitro and in vivo level on the promotion of periodontal and peri-implant bone wound healing, This paper will conclude with a future perspective of ongoing studies in the human clinical trial arena using growth and osteoinductive factors to promote periodontal tissue regeneration and alveolar bone repair in the oral cavity.