INHIBITING EFFECTS OF SEROTONIN AND SEROTONIN ANTAGONISTS ON THE MIGRATION OF MONONUCLEAR LEUKOCYTES
INHIBITING EFFECTS OF SEROTONIN AND SEROTONIN ANTAGONISTS ON THE MIGRATION OF MONONUCLEAR LEUKOCYTES
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DOI：
10.3109/08923979309025997
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发表时间：
1993-01-01
影响因子：
3.3
通讯作者：
SUNDSTROM, E
中科院分区：
文献类型：
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作者：
BONDESSON, L;NORDLIND, K;SUNDSTROM, E
应用封闭毛细管迁移技术研究了5-羟色胺及其拮抗剂酮色林、甲硫替平和ICS-205-930对白细胞迁移的影响。5-羟色胺在10（-4）和10（-6）-10（-10）mol/l时抑制单核白细胞的迁移。ICS-205-930（10（-4）mol/l）、酮色林（10（-4）和10（-8）-10（-10）mol/l）以及甲硫替平（10（-4）和10（-6）-10（-8）mol/l）也可抑制单核白细胞迁移。5-羟色胺及其拮抗剂对多形核白细胞的迁移无抑制作用。因此，5-羟色胺和5-羟色胺拮抗剂均可抑制单核白细胞迁移。
The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at 10(-4) and 10(-6)-10(-10) mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10(-4) mol/l, ketanserin at 10(-4) and 10(-8)-10(-10) mol/l and methiotepine at 10(-4) and 10(-6)-10(-8) mol/l. No inhibiting effects of serotonin br the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.