Non-albicans Candida Infection: An Emerging Threat.
Non-albicans Candida Infection: An Emerging Threat.
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DOI：
10.1155/2014/615958
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Mathew, Stephen
中科院分区：
文献类型：
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作者：
Deorukhkar, Sachin C;Saini, Santosh;Mathew, Stephen
在过去几十年中，传染病的性质发生了深刻的变化。真菌曾经被认为是非致病性的或毒性较小的，现在被认为是免疫功能低下和重症患者发病和死亡的主要原因。念珠菌是最常见的真菌病原体。白色念珠菌是念珠菌病的主要致病菌。然而，最近观察到向非白色念珠菌的转变。这些非白色念珠菌属菌种对常用抗真菌药物的敏感性降低。在本研究中，我们调查了非白色念珠菌的患病率。对临床分离的念珠菌进行毒力因子和药物敏感性分析。共检出念珠菌523株。从各种临床标本中分离。非白色念珠菌属是分离的主要病原体。非白色念珠菌也表现出曾经归因于白色念珠菌的毒力因子的产生。非白念珠菌对唑类抗真菌药耐药率高。因此，可以得出结论，非白色念珠菌已成为感染的重要原因。它们从临床标本中的分离不能再作为非致病性分离株而被忽视，也不能作为污染物而被忽视。
The very nature of infectious diseases has undergone profound changes in the past few decades. Fungi once considered as nonpathogenic or less virulent are now recognized as a primary cause of morbidity and mortality in immunocompromised and severely ill patients. Candida spp. are among the most common fungal pathogens. Candida albicans was the predominant cause of candidiasis. However, a shift toward non-albicans Candida species has been recently observed. These non-albicans Candida species demonstrate reduced susceptibility to commonly used antifungal drugs. In the present study, we investigated the prevalence of non-albicans Candida spp. among Candida isolates from various clinical specimens and analysed their virulence factors and antifungal susceptibility profile. A total of 523 Candida spp. were isolated from various clinical specimens. Non-albicans Candida species were the predominant pathogens isolated. Non-albicans Candida species also demonstrated the production of virulence factors once attributed to Candida albicans. Non-albicans Candida demonstrated high resistance to azole group of antifungal agents. Therefore, it can be concluded that non-albicans Candida species have emerged as an important cause of infections. Their isolation from clinical specimen can no longer be ignored as a nonpathogenic isolate nor can it be dismissed as a contaminant.