Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development
Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana: effects on growth and motor development
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DOI：
10.1093/ajcn/86.2.412
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发表时间：
2007-08-01
影响因子：
7.1
通讯作者：
Dewey, Kathryn G.
中科院分区：
文献类型：
--
作者：
Adu-Afarwuah, Seth;Lartey, Anna;Dewey, Kathryn G.
背景：补充食品的微量营养素含量低与许多人群的生长缓慢有关。一种潜在的低成本解决方案是用 Sprinkles (SP) 粉、可压碎的 Nutritabs (NT) 片剂或高能量（108 kcal/d）脂肪基 Nutributter (NB) 来家庭强化辅食。目的：目的是检验以下假设：在家庭准备的辅食中添加多种微量营养素会促进生长，并且在添加脂肪能量的情况下效果最佳。设计：我们随机分配了 313 名加纳人6 至 12 个月大的婴儿每天接受分别含有 6、16 和 19 种维生素和矿物质的 SP、NT 或 NB。我们评估了第 6、9 和 12 个月时的人体测量状态； 6 个月和 12 个月时的微量营养素状况； 12 个月时运动发育；和每周发病率。未随机选择进行干预（非干预；NI）的婴儿 (n = 96) 在 12 个月时进行评估。结果：各组在基线时没有显着差异，只是 NB 组的男孩比例较高且体重稍重。辍学率（15/313）较低。 12 个月时，在控制初始尺寸后，NB 组的年龄别体重 z 评分 (WAZ) (-0.49 +/- 0.54) 和年龄别身长 z 评分 (LAZ) (-0.20 +/- 0.54) 显着高于 NT 组（WAZ：-0.67 +/- 0.54；LAZ：-0.39 +/- 0.54）以及 NT 和 SP 组的总和（WAZ：-0.65 +/- 0.54；LAZ：-0.38 +/- 0.54）；与NI组（WAZ：-0.74+/-1.1；LAZ：-0.40+/-1.0）差异不显着。与干预组（SP：39％；NT：36％；NB：49％）相比，NI 婴儿在 12 个月时能够独立行走的比例较低（25％）。结论：与不干预相比，所有 3 种补充剂对 12 个月时运动里程碑的获得都有积极影响，但只有 NB 影响生长。
Background: The low micronutrient content of complementary foods is associated with growth faltering in many populations. A potential low-cost solution is the home fortification of complementary foods with Sprinkles (SP) powder, crushable Nutritabs (NT) tablets, or energy-dense (108 kcal/d), fat-based Nutributter (NB).Objective: The objective was to test the hypothesis that multiple micronutrients added to home-prepared complementary foods would increase growth and that the effect would be greatest in the presence of added energy from fat.Design: We randomly assigned 313 Ghanaian infants to receive SP, NT, or NB containing 6, 16, and 19 vitamins and minerals, respectively, daily from 6 to 12 mo of age. We assessed anthropometric status at 6, 9, and 12 mo; micronutrient status at 6 and 12 mo; motor development at 12 mo; and morbidity weekly. Infants (n = 96) not randomly selected for the intervention (nonintervention; NI) were assessed at 12 mo.Results: The groups did not differ significantly at baseline, except that the NB group had a higher proportion of boys and weighed slightly more. The dropout rate (15/313) was low. At 12 mo, after control for initial size, the NB group had a significantly greater weight-for-age z score (WAZ) (-0.49 +/- 0.54) and length-for-age z score (LAZ) (-0.20 +/- 0.54) than did the NT group (WAZ: -0.67 +/- 0.54; LAZ: -0.39 +/- 0.54) and the NT and SP groups combined (WAZ: -0.65 +/- 0.54; LAZ: -0.38 +/- 0.54); the difference with the NI group (WAZ: -0.74 +/- 1.1; LAZ: -0.40 +/- 1.0) was not significant. A lower percentage of the NI infants (25%) than of the intervention groups (SP: 39%; NT: 36%; NB: 49%) could walk independently by 12 mo.Conclusion: All 3 supplements had positive effects on motor milestone acquisition by 12 mo compared with no intervention, but only NB affected growth.