Cyclic AMP phosphodiesterase and its inhibitor in slime mould development.
Cyclic AMP phosphodiesterase and its inhibitor in slime mould development.
复制标题
环AMP磷酸二酯酶及其在粘菌发育中的抑制剂。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
M. Every
中科院分区：
文献类型：
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作者：
G. Gerisch;D. Malchow;V. Riedel;E. Müller;M. Every
环腺苷-3 ′，5 ′-单磷酸（环AMP）作为一种趋化因子，在黏菌Dtctyosteltum discoideum中引起细胞聚集1，2。这种生物体中的聚集是生长阶段和发育的第二阶段之间的联系，在第二阶段中，细胞合作并分化形成多细胞子实体。这一发现表明，环腺苷酸还介导了除趋化作用以外的发育功能3，表明环腺苷酸合成和破坏的调节在D.盘状突。
CYCLIC adenosine-3′,5′-monophosphate (cyclic AMP) acts as a chemotactic factor causing cell aggregation in the slime mould, Dtctyosteltum discoideum1,2. Aggregation in this organism is the link between the growth phase and the second phase of development, in which cells cooperate and differentiate to form a multicellular fruiting body. The finding that cyclic AMP also mediates developmental functions other than chemotaxis3 suggests that regulation of cyclic AMP synthesis and destruction is important in the control of morphogenesis in D. discoideum.