Diffusion-weighted imaging of malignant breast tumors - The usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension
Diffusion-weighted imaging of malignant breast tumors - The usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension
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DOI：
10.1097/01.rct.0000171913.74086.1b
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发表时间：
2005-09-01
影响因子：
1.3
通讯作者：
Hayakawa, K
中科院分区：
文献类型：
--
作者：
Woodhams, R;Matsunaga, K;Hayakawa, K
作者使用乳房扩散加权成像(DWI)来诊断乳腺癌并识别癌症扩展。EPI行各向同性弥散加权成像。计算表观扩散系数(ADC)值并显示在ADC图上。作者将低ADC值的分布与肿瘤的病理范围进行了比较。乳腺癌的ADC值为1.12+/-0.24X10(-3)mm(2)/S，低于正常乳腺组织。浸润性导管癌的ADC值低于非浸润性导管癌。以ADC值<1.6×10~(-3)mm(-3)mm(2)/S为阈值诊断乳腺癌的灵敏度为95%。在所有病例中，75%的病例显示低ADC值随着肿瘤的扩展而精确分布。低估的原因是出血的易感性伪影和空间分辨率的限制。良性增生性病变的ADC值较低。作者认为，弥散加权成像在乳腺癌的诊断中具有潜在的临床应用价值。
The authors used breast diffusion-weighted imaging (DWI) to diagnose breast cancer and identify cancer extension. Isotropic DWI was performed with EPI. The apparent diffusion coefficient (ADC) value was calculated and displayed on an ADC map. The authors compared between the distribution of low ADC values and pathologic cancer extension. The mean ADC value of breast cancer was 1.12 +/- 0.24 X 10(-3) mm(2)/s, which was lower than that of normal breast tissue. The ADC value for invasive ductal carcinoma was lower than that of noninvasive ductal carcinoma. The sensitivity of the ADC value for breast cancer using a threshold of less than 1.6 X 10(-3) mm(2)/s was 95%. Seventy-five percent of all cases showed precise distribution of low ADC value as cancer extension. The causes of underestimation were susceptibility artifact from bleeding and the limit of spatial resolution. Benign proliferative change showed a low ADC value. The authors conclude that DWI has a potential for clinical appreciation in detecting breast cancer.