Effects of One Year of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
Effects of One Year of Vitamin D and Marine Omega-3 Fatty Acid Supplementation on Biomarkers of Systemic Inflammation in Older US Adults
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DOI：
10.1373/clinchem.2019.306902
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发表时间：
2019-12-01
影响因子：
9.3
通讯作者：
Cook, Nancy R.
中科院分区：
文献类型：
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作者：
Costenbader, Karen H.;MacFarlane, Lindsey A.;Cook, Nancy R.
背景技术背景：观察性研究表明，维生素D和海洋ω-3脂肪酸（n-3 FA）补充剂与较低的全身炎症有关。方法：随机，双盲，安慰剂对照的维生素D和OmegA-3 TriaL（VITAL）测试维生素D（2000 IU/天）和/或n-3 FA（1 g/天）补充剂在2 × 2析因设计中的女性>= 55和男性>= 50岁。我们评估了随机接受维生素D + n-3 FA（392例）、维生素D（392例）、n-3 FA（392例）或仅接受安慰剂（385例）的受试者从基线至1年时白细胞介素（IL）-6、肿瘤坏死因子受体2（TNFR 2）和高敏C反应蛋白（hsCRP）浓度的变化。几何平均值和百分比变化进行了比较，调整基线factors.RESULTS：基线特征平衡良好。在活性组中，25-OH维生素D升高39%，n-3 FA升高55%，而安慰剂组变化极小。这两种补充剂都没有在1年时降低生物标志物。维生素D导致IL-6升高8.2%（95% CI，1.5%-15.3%;校正P = 0.02），但TNFR 2和hsCRP没有升高。在784名接受维生素D治疗的患者中，hsCRP在低水平（
BACKGROUND: Observational studies suggest vitamin D and marine omega-3 fatty acid (n-3 FA) supplements are associated with lower systemic inflammation. However, past trials have been inconsistent.METHODS: The randomized, double-blind, placebo-controlled VITamin D and OmegA-3 TriaL (VITAL) tested vitamin D (2000 IU/day) and/or n-3 FA (1 g/day) supplementation in a 2 x 2 factorial design among women >= 55 and men >= 50 years of age. We assessed changes in interleukin (IL)-6, tumor necrosis factor receptor 2 (TNFR2), and high-sensitivity C-reactive protein (hsCRP) concentrations from baseline to 1 year among participants randomized to vitamin D + n-3 FA (392), vitamin D (392), n-3 FA (392), or placebo only (385). Geometric means and percent changes were compared, adjusting for baseline factors.RESULTS: Baseline characteristics were well balanced. In the active arms, 25-OH vitamin D rose 39% and n-3 FA rose 55% vs minimal change in placebo arms. Neither supplement reduced biomarkers at 1 year. Vitamin D resulted in 8.2% higher IL-6 (95% CI, 1.5%-15.3%; adjusted P = 0.02), but TNFR2 and hsCRP did not. Among 784 receiving vitamin D, hsCRP increased 35.7% (7.8%-70.9%) in those with low (