Constitutional mechanisms of vulnerability and resilience to nicotine dependence.
Constitutional mechanisms of vulnerability and resilience to nicotine dependence.
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DOI：
10.1038/mp.2009.16
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发表时间：
2009-07
影响因子：
11
通讯作者：
Scott D
中科院分区：
文献类型：
--
作者：
Hiroi N;Scott D
尼古丁依赖的核心本质在个体如何成为和保持吸烟者的巨大差异中显而易见。已有行为特征的人更有可能产生尼古丁依赖，并在尝试戒烟时遇到困难。许多分子因素可能以复杂的方式导致尼古丁依赖和行为特征发展的个体差异。然而，此类分子的鉴定受到尼古丁依赖性表型复杂性以及分子影响尼古丁依赖性要素的复杂方式的阻碍。我们假设尼古丁依赖部分是尼古丁与预先存在的行为特征之间相互作用的结果。这一观点表明，识别这些预先存在的行为特征的分子基础将有助于开发减少吸烟依赖和帮助吸烟者戒烟的有效方法。
The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual variations in the development of nicotine dependence and behavioral traits in complex manners. However, the identification of such molecules has been hampered by the phenotypic complexity of nicotine dependence and the complex ways molecules affect elements of nicotine dependence. We hypothesize that nicotine dependence is, in part, a result of interactions between nicotine and pre-existing behavioral traits. This perspective suggests that the identification of the molecular bases of such pre-existing behavioral traits will contribute to the development of effective methods for reducing smoking dependence and for helping smokers to quit.