Casein kinase 1 and Wnt/β-catenin signaling
Casein kinase 1 and Wnt/β-catenin signaling
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DOI：
10.1016/j.ceb.2014.08.003
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发表时间：
2014-12-01
影响因子：
7.5
通讯作者：
Cruciat, Cristina-Maria
中科院分区：
文献类型：
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作者：
Cruciat, Cristina-Maria
酪蛋白激酶1 （CK1）成员在Wnt/ β -连环蛋白信号传导中起着关键的和进化保守作用。它们磷酸化几个通路成分并发挥双重功能，既作为Wnt激活剂又作为Wnt抑制剂。最近的发现表明CK1成员以协调的方式调节对Wnt的早期反应，特别是它们的酶活性受到调节。在这里，我简要介绍了CK1在Wnt/ β -catenin信号传导中的功能和调控。
Casein kinase 1 (CK1) members play a critical and evolutionary conserved role in Wnt/beta-catenin signaling. They phosphorylate several pathway components and exert a dual function, acting as both Wnt activators and Wnt inhibitors. Recent discoveries suggest that CK1 members act in a coordinated manner to regulate early responses to Wnt and notably that their enzymatic activity is regulated. Here, I provide a brief update of CK1 function and regulation in Wnt/beta-catenin signaling.