Workshop on Idiopathic Pulmonary Fibrosis in Older Adults
Workshop on Idiopathic Pulmonary Fibrosis in Older Adults
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DOI：
10.1378/chest.09-3006
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发表时间：
2010-09-01
期刊：
影响因子：
9.6
通讯作者：
High, Kevin P.
中科院分区：
文献类型：
--
作者：
Castriotta, Richard J.;Eldadah, Basil A.;High, Kevin P.
特发性肺纤维化(IPF)是一种与临床表现和进展速度有关的异质性疾病，对老年人的影响不成比例。IPF的诊断是描述性的，以临床、放射学和组织病理学检查为基础，由于观察者之间缺乏共识和缺乏共识的定义，最终诊断受到阻碍。目前还没有有效的治疗方法。细胞、分子、遗传和环境风险因素已被确定为IPF的危险因素，但启动事件和临床前阶段的特征尚不清楚。IPF主要是一种老年人的疾病，正常衰老过程可能会显著影响IPF的发展。然而，在基础的、翻译的或临床的IPF研究中，衰老的生物学和针对这一人群的医疗保健原则通常被忽视。2009年8月，专科教授协会与美国胸科医师学会、美国老年医学会、国家老龄研究所和国家心肺血液研究所合作举办了一次研讨会，总结如下，以回顾已知的情况，找出老龄化与IPF之间的研究差距，并为未来的研究提出优先领域。回答所确定的问题的努力将需要整合老年病学、老年学和肺部研究，但这些努力在改善对IPF患者的护理方面具有巨大的潜力。《胸部2010》138(3)：693-703
Idiopathic pulmonary fibrosis (IPF), a heterogeneous disease with respect to clinical presentation and rates of progression, disproportionately affects older adults. The diagnosis of IPF is descriptive, based on clinical, radiologic, and histopathologic examination, and definitive diagnosis is hampered by poor interobserver agreement and lack of a consensus definition. There are no effective treatments. Cellular, molecular, genetic, and environmental risk factors have been identified for IPF, but the initiating event and the characteristics of preclinical stages are not known. IPF is predominantly a disease of older adults, and the processes underlying normal aging might significantly influence the development of IPF. Yet, the biology of aging and the principles of medical care for this population have been typically ignored in basic, translational, or clinical IPF research. In August 2009, the Association of Specialty Professors, in collaboration with the American College of Chest Physicians, the American Geriatrics Society, the National Institute on Aging, and the National Heart, Lung, and Blood Institute, held a workshop, summarized herein, to review what is known, to identify research gaps at the interface of aging and IPF, and to suggest priority areas for future research. Efforts to answer the questions identified will require the integration of geriatrics, gerontology, and pulmonary, research, but these efforts have great potential to improve care for patients with IPF. CHEST 2010; 138(3):693-703