Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia
Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia
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DOI：
10.1016/j.clinph.2013.08.006
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发表时间：
2014-03-01
影响因子：
4.7
通讯作者：
Berardelli, Alfredo
中科院分区：
文献类型：
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作者：
Conte, Antonella;Rocchi, Lorenzo;Berardelli, Alfredo
目的：目的：探讨局部性手肌张力障碍（FHD）患者在初级体感皮层（S1）接受θ波刺激（TBS）后，其体感时间辨别阈（STDT）和书写功能的变化。方法：12例FHD患者在患手对侧S1接受间歇性、连续性或假TBS（iTBS、cTBS、sham TBS）刺激前后，进行STDT测试和书写任务。12名健康受试者进行iTBS和cTBS超过S1和STDT值进行了测试的右手之前和之后TBS。结果：基线STDT值高于健康受试者的患手和健手。在患者和健康受试者中，iTBS降低，而cTBS增加STDT值，并且在两组中达到相似的程度。在患者中，尽管iTBS后STDT值降低，但未恢复正常。S1调制并没有提高书写performance.Conclusions：在患者中，S1正常反应诱导同伦突触可塑性的协议。负责STDT的抑制性interneuron活动是altered.Significance：异常的时间歧视的病理生理机制不同，负责FHD的运动症状。(C)2013年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To investigate whether theta burst stimulation (TBS) applied over primary somatosensory cortex (S1) modulates somatosensory temporal discrimination threshold (STDT) and writing performances in patients with focal hand dystonia (FHD).Methods: Twelve patients with FHD underwent STDT testing and writing tasks before and after intermittent, continuous, or sham TBS (iTBS, cTBS, sham TBS) over S1 contralateral to the affected hand. Twelve healthy subjects underwent iTBS and cTBS over S1 and STDT values were tested on the right hand before and after TBS.Results: Baseline STDT values were higher in patients than in healthy subjects on both the affected and unaffected hand. In patients and healthy subjects iTBS decreased, whereas cTBS increased STDT values and did so to a similar extent in both groups. In patients, although STDT values decreased after iTBS, they did not normalize. S1 modulation did not improve the writing performance.Conclusions: In patients, S1 responds normally to protocols inducing homotopic synaptic plasticity. The inhibitory interneuron activity responsible for STDT is altered.Significance: The pathophysiological mechanisms underlying abnormal temporal discrimination differ from those responsible for motor symptoms in FHD. (C) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.