Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics.
Selective Changes of GABA(A) Channel Subunit mRNAs in the Hippocampus and Orbitofrontal Cortex but not in Prefrontal Cortex of Human Alcoholics.
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DOI：
10.3389/fncel.2011.00030
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发表时间：
2011
影响因子：
5.3
通讯作者：
Birnir B
中科院分区：
文献类型：
--
作者：
Jin Z;Bazov I;Kononenko O;Korpi ER;Bakalkin G;Birnir B
酒精依赖是一种常见的慢性复发性障碍。酒精依赖的发展与大脑GABAA通道介导的神经传递和可塑性的变化有关。我们用实时定量聚合酶链式反应检测了酒精依赖者和非酒精依赖者三个脑区GABAA通道亚单位基因的mRNA表达。酒精受试者特定脑区选择性GABAA通道亚单位mRNAs水平发生改变。海马齿状回α-1、α-4、α-5、β-1和γ-1亚单位表达显著增加，眶-额叶皮质β-2和δ亚单位表达减少，而背外侧前额叶无明显变化。这些数据增加了我们对GABAA通道在酒精依赖发展中的作用的理解。
Alcohol dependence is a common chronic relapsing disorder. The development of alcohol dependence has been associated with changes in brain GABAA channel-mediated neurotransmission and plasticity. We have examined mRNA expression of the GABAA channel subunit genes in three brain regions in individuals with or without alcohol dependence using quantitative real-time PCR assay. The levels of selective GABAA channel subunit mRNAs were altered in specific brain regions in alcoholic subjects. Significant increase in the α1, α4, α5, β1, and γ1 subunit mRNAs in the hippocampal dentate gyrus region, and decrease in the β2 and δ subunit mRNAs in the orbitofrontal cortex were identified whereas no changes in the dorsolateral prefrontal cortex were detected. The data increase our understanding of the role of GABAA channels in the development of alcohol dependence.
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影响因子：
3.4
作者：
Bazov, Igor;Kononenko, Olga;Bakalkin, Georgy
通讯作者：
Bakalkin, Georgy
影响因子：
2.9
作者：
Johansson, Sofia;Fuchs, Andrea;Ekstrom, Tomas J.
通讯作者：
Ekstrom, Tomas J.
影响因子：
3.6
作者：
Cagetti, E;Liang, J;Olsen, RW
通讯作者：
Olsen, RW
影响因子：
4.7
作者：
Baur, Roland;Kaur, Kuldeep H.;Sigel, Erwin
通讯作者：
Sigel, Erwin
影响因子：
4.2
作者：
Buckley, S. Tracey;Foley, Philomena F.;Dodd, Peter R.
通讯作者：
Dodd, Peter R.