Definition of intractable epilepsy.
Definition of intractable epilepsy.
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DOI：
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发表时间：
2011
期刊：
影响因子：
0.9
通讯作者：
S. Sinha;Khurram A Siddiqui
中科院分区：
文献类型：
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作者：
S. Sinha;Khurram A Siddiqui
定义顽固性癫痫不仅对于识别高达 40% 的药物治疗难治性患者至关重要，而且还有助于出于研究目的选择和比较此类患者。我们仍然无法找到理想的定义。在制定耐药性癫痫的定义时，需要考虑多种因素，包括抗癫痫药物（AED）失败的次数、癫痫发作频率和无反应持续时间、病因和癫痫综合征。文献中使用的大多数定义都同意 AED 失败的次数，似乎是 2 或 3 次，然而，癫痫发作频率和时间因素各不相同。国际抗癫痫联盟提出了耐药性癫痫的定义：对 2 种耐受且适当选择和使用的 AED 方案进行充分试验失败。目前，这可以为临床和研究环境提供操作定义。然而，随着新数据和新疗法的出现，难处理的标准可能会改变。
Defining intractable epilepsy is essential not only to identify up to 40% of patients refractory to pharmacological management, but also to facilitate selection and comparison of such patients for research purposes. The ideal definition still eludes us. Multiple factors including number of antiepileptic drug (AED) failures, seizure frequency and duration of unresponsiveness, etiology, and epilepsy syndromes are considered in formulating the definition of pharmaco-resistant epilepsy. Most definitions used in the literature agree on the number of AED failures, which seem to be 2 or 3, however, the seizure frequency and time factor are varied. The International League Against Epilepsy proposed a definition of drug-resistant epilepsy as a failure of adequate trials of 2 tolerated and appropriately chosen and used AED schedules. This for now, could provide an operational definition for clinical and research settings. However, with emergence of new data and novel treatments the criteria for intractability may change.