Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China
Drinking water arsenic exposure and blood pressure in healthy women of reproductive age in Inner Mongolia, China
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DOI：
10.1016/j.taap.2007.04.003
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发表时间：
2007-08-01
影响因子：
3.8
通讯作者：
Mumford, Judy L.
中科院分区：
文献类型：
--
作者：
Kwok, Richard K.;Mendola, Pauline;Mumford, Judy L.
在先前的调查中评估的与饮用水砷含量升高和高血压患病率有关的极高暴露水平使得很难推断较低暴露水平下对血管的潜在影响。本文对中国内蒙古某地区8790名孕妇进行了横断面研究，研究对象为饮用水砷暴露梯度。本研究观察到，随着饮用水砷含量的增加，收缩压水平也会升高，但接触砷的水平比以前文献报道的要低。与参考类别（低于检测限20 μ g As/L）相比，随着饮用水砷浓度从21 μ g As/L增加到50、51 μ g As/L增加到100 μ g As/L，总体人群平均收缩压分别上升1.29 mm Hg （95% CI 0.82, 1.75）、1.28 mm Hg （95% CI 0.49, 2.07）和2.22 mm Fig （95% CI 1.46, 2.97）。控制年龄和体重（n = 3260），随着饮用水砷浓度的增加，人群平均收缩压分别上升1.88 mm Hg (95% CI 1.03, 2.73), 3.90 mm Hg （95% CI 2.52, 5.29）和6.83 mm Fig （95% CI 5.39, 8.27）。对于舒张压的影响，虽然有统计学意义，但不像收缩压那么明显。平均舒张压上升0.78毫米汞柱(95%氯0.39,1.16),1.57毫米汞柱(95% CI 0.91, 2.22)和1.32毫米汞柱(95%氯0.70,1.95),分别为总人口和玫瑰2.11毫米无花果(95% CI 1.38, 2.84), 2.74毫米汞柱(95% CI 1.55, 3.93),和3.08毫米汞柱(95% CI 1.84, 4.31),分别为调整人口(n = 3260)饮用水砷浓度的21岁到50岁,51 - 100,> 100μg / L。如果我们的研究结果在其他人群中得到证实，可归因于饮用水砷的心血管疾病的潜在负担是显著的。(c) 2007爱思唯尔公司版权所有。
The extremely high exposure levels evaluated in prior investigations relating elevated levels of drinking water arsenic and hypertension prevalence make extrapolation to potential vascular effects at lower exposure levels very difficult. A cross-sectional study was conducted on 8790 women who had recently been pregnant in an area of Inner Mongolia, China known to have a gradient of drinking water arsenic exposure. This study observed increased systolic blood pressure levels with increasing drinking water arsenic, at lower exposure levels than previously reported in the literature. As compared to the referent category (below limit of detection to 20 mu g of As/L), the overall population mean systolic blood pressure rose 1.29 mm Hg (95% CI 0.82, 1.75), 1.28 mm Hg (95% CI 0.49, 2.07), and 2.22 mm Fig (95% Cl 1.46, 2.97) as drinking water arsenic concentration increased from 21 to 50, 51 to 100, and > 100 mu g of As/L, respectively. Controlling for age and body weight (n = 3260), the population mean systolic blood pressure rose 1.88 mm Hg (95% CI 1.03, 2.73), 3.90 mm Hg (95% CI 2.52, 5.29), and 6.83 mm Fig (95% CI 5.39, 8.27) as drinking water arsenic concentration increased, respectively. For diastolic blood pressure effect, while statistically significant, was not as pronounced as systolic blood pressure. Mean diastolic blood pressure rose 0.78 mm Hg (95% Cl 0.39, 1.16), 1.57 mm Hg (95% CI 0.91, 2.22) and 1.32 mm Hg (95% Cl 0.70, 1.95), respectively, for the overall population and rose 2.11 mm Fig (95% CI 1.38, 2.84), 2.74 mm Hg (95% CI 1.55, 3.93), and 3.08 mm Hg (95% CI 1.84, 4.31), respectively, for the adjusted population (n=3260) at drinking water arsenic concentrations of 21 to 50, 51 to 100, and > 100 mu g of As/L. If our study results are confirmed in other populations, the potential burden of cardiovascular disease attributable to drinking water arsenic is significant. (c) 2007 Elsevier Inc. All rights reserved.