Retardation of fast axonal transport in wobbler mice.
Retardation of fast axonal transport in wobbler mice.
复制标题
摇摆小鼠快速轴突运输的延迟。
DOI：
10.1002/mus.880160517
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发表时间：
1993
期刊：
影响因子：
3.4
通讯作者：
McQuarrie,IG
中科院分区：
文献类型：
--
作者：
Mitsumoto,H;Kurahashi,K;Jacob,JM;McQuarrie,IG
To investigate axonal function in a model of early motor neuron disease, we examined fast and slow components of anterograde axonal transport in the less-affected hindlimb motor neurons of wobbler mice. To study the fast component (FC), we injected tritiated amino acids into the lumbar spinal cord and retrieved the sciatic nerve after 2 or 3 h. The transport distance was the extent of the plateau of labeling; regression analysis indicated that FC was 25% slower in wobbler mice than in unaffected littermates (P< 0.01). To study slow component (SC),[35 S] methionine was injected. Transport distances were to the peaks of labeling for structural proteins after 2 or 3 weeks. Rates for each subcomponent (SCa and SCb) were unaffected by wobbler disease. Because the rate of retrograde FC is also unaffected (Mitsumoto et al., Muscle & Nerve 13: 121–126, 1990), we conclude that wobbler disease specifically retards anterograde FC in less-affected hindlimb motor neurons, whereas all components of axonal transport are retarded in forelimb motor neurons.© 1993 John Wiley & Soncs, Inc.
