Major depressive disorder and immunity. Role of age, sex, severity, and hospitalization.
Major depressive disorder and immunity. Role of age, sex, severity, and hospitalization.
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DOI：
10.1001/archpsyc.1989.01810010083011
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发表时间：
1989
影响因子：
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通讯作者：
S. Schleifer;S. Keller;R. Bond;Jacob Cohen;M. Stein
中科院分区：
文献类型：
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作者：
S. Schleifer;S. Keller;R. Bond;Jacob Cohen;M. Stein
抑郁症和免疫力改变之间的联系已经被提出，但尚未得到一致的证明。我们研究了91例单相抑郁症患者，发现患者与同期研究的匹配对照组在有丝分裂原诱导的淋巴细胞增殖、淋巴细胞亚群和自然杀伤细胞活性方面无平均差异。然而，抑郁症患者和对照组之间在有丝分裂原反应和T4淋巴细胞数量方面存在显着的年龄相关差异。与对照组中与年龄相关的有丝分裂原反应和T4细胞增加相反，抑郁症患者的淋巴细胞反应或T4淋巴细胞数量并没有随着年龄的增长而增加。抑郁的严重程度和住院状态也与免疫系统的变化有关。免疫力改变似乎不是抑郁症的一个特定生物学相关因素，但可能发生在抑郁症患者的亚组中。
An association between depression and altered immunity has been suggested but has not been consistently demonstrated. We have studied 91 patients with unipolar major depressive disorder, and no mean differences were found between the patients and concurrently studied matched controls in mitogen-induced lymphocyte proliferation, lymphocyte subsets, and natural killer cell activity. There were, however, significant age-related differences between the depressed patients and controls in mitogen responses and in the number of T4 lymphocytes. In contrast to age-related increases in mitogen response and in T4 cells in controls, depressed patients did not show increased lymphocyte responses or numbers of T4 lymphocytes with advancing age. Severity of depression and hospitalization status were also associated with immune system changes. Altered immunity does not appear to be a specific biologic correlate of major depressive disorder but may occur in subgroups of depressed patients.