Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration.
Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration.
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DOI：
10.2147/ijn.s44393
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发表时间：
2013
影响因子：
8
通讯作者：
Xiao Y
中科院分区：
文献类型：
--
作者：
Gu W;Wu C;Chen J;Xiao Y
纳米技术是一个充满活力的研究领域，其重要应用之一是在生物医学科学中。在生物医学应用中，靶向给药是研究最广泛的课题之一。纳米结构颗粒和支架已被广泛研究，以提高现有治疗方法的治疗效果和特异性。同样，这项技术也被用于治疗包括骨再生在内的骨骼疾病。在这篇综述中，我们总结和强调了纳米粒子和支架在治疗癌症、骨转移、骨肉瘤、骨感染和炎症性疾病、骨关节炎以及骨再生方面的最新进展。用于将脱氧核糖核酸和核糖核酸分子运送到特定骨骼部位进行基因治疗的纳米颗粒也包括在内。纳米颗粒在骨骼疾病中的意义的研究才刚刚开始，已经显示出一些有希望的潜力。还需要进行进一步的研究，特别是评估靶向递送和生物活性支架，以进一步提高它们的有效性，然后才能将其用于临床。
Nanotechnology is a vigorous research area and one of its important applications is in biomedical sciences. Among biomedical applications, targeted drug delivery is one of the most extensively studied subjects. Nanostructured particles and scaffolds have been widely studied for increasing treatment efficacy and specificity of present treatment approaches. Similarly, this technique has been used for treating bone diseases including bone regeneration. In this review, we have summarized and highlighted the recent advancement of nanostructured particles and scaffolds for the treatment of cancer bone metastasis, osteosarcoma, bone infections and inflammatory diseases, osteoarthritis, as well as for bone regeneration. Nanoparticles used to deliver deoxyribonucleic acid and ribonucleic acid molecules to specific bone sites for gene therapies are also included. The investigation of the implications of nanoparticles in bone diseases have just begun, and has already shown some promising potential. Further studies have to be conducted, aimed specifically at assessing targeted delivery and bioactive scaffolds to further improve their efficacy before they can be used clinically.