TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis: Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló's Concentric Sclerosis.
TSPO PET With 18F-GE-180 to Differentiate Variants of Multiple Sclerosis: Relapsing-Remitting Multiple Sclerosis, Tumefactive Demyelination, and Baló's Concentric Sclerosis.
复制标题
使用 18F-GE-180 的 TSPO PET 可区分多发性硬化症的变体：复发缓解型多发性硬化症、肿瘤性脱髓鞘病和 Baló 同心圆硬化症。
DOI：
10.1097/rlu.0000000000003220
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发表时间：
2020
影响因子：
10.6
通讯作者：
A. Danek
中科院分区：
文献类型：
--
作者：
Stefanie Völk;M. Unterrainer;N. Albert;J. Havla;L. Gerdes;Minh Schumacher;M. Brendel;L. Kaiser;K. Adorjan;R. Rupprecht;P. Bartenstein;T. Kümpfel;A. Danek
PET靶向转运蛋白（TSPO）表达是一种检测神经炎症的有趣方法，因为TSPO在活化的巨噬细胞和小胶质细胞中上调。考虑到多发性硬化症（MS）变异的病理生理学变化，我们比较了使用F-GE-180的TSPO PET在3种不同的中枢神经系统脱髓鞘疾病中的作用：复发缓解型MS，肿胀型MS和Baló同心圆硬化症。除MRI外，神经炎症及其PET模式的可视化可能有助于准确区分和监测中枢神经系统脱髓鞘。
PET targeting the translocator protein (TSPO) expression is an interesting approach to detect neuroinflammation, as TSPO is upregulated in activated macrophages and microglia. Considering the variable pathophysiology of multiple sclerosis (MS) variants, we compare TSPO PET using F-GE-180 in 3 different demyelinating diseases of the central nervous system: relapsing-remitting MS, tumefactive MS, and Baló's concentric sclerosis. Visualization of neuroinflammation and its PET patterns in addition to MRI may contribute to accurate distinction and monitoring of central nervous system demyelination.