The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting.
The effect of an abuse-deterrent opioid formulation (OxyContin) on opioid abuse-related outcomes in the postmarketing setting.
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DOI：
10.1002/cpt.390
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发表时间：
2016-09
影响因子：
6.7
通讯作者：
Dart RC
中科院分区：
文献类型：
--
作者：
Coplan PM;Chilcoat HD;Butler SF;Sellers EM;Kadakia A;Harikrishnan V;Haddox JD;Dart RC
重新配制了一种缓释阿片类镇痛药（奥施康定，OC），具有滥用威慑特性，以阻止滥用。本报告检查了10项研究中口服和非口服途径滥用、医生购物和死亡的变化，这些研究在重新配制后3.5年进行。计算OC重新配制后1年至3年的OC滥用变化，并根据处方变化进行调整。在国家毒物中心监测系统中，OC的滥用减少了48%，在国家药物治疗系统中减少了32%，在索赔数据库中处方OC的个人中减少了27%。购买OC的医生减少了50%。向制造商报告的过量死亡人数下降了65%。没有滥用威慑特性的其他阿片类药物的滥用比OC晚2年减少，幅度较小，表明OC减少不是由于更广泛的阿片类药物干预。与制剂一致，非口服滥用的降幅大于口服滥用。滥用威慑阿片类药物可以减轻慢性疼痛患者的滥用和过量风险。
An extended‐release opioid analgesic (OxyContin, OC) was reformulated with abuse‐deterrent properties to deter abuse. This report examines changes in abuse through oral and nonoral routes, doctor‐shopping, and fatalities in 10 studies 3.5 years after reformulation. Changes in OC abuse from 1 year before to 3 years after OC reformulation were calculated, adjusted for prescription changes. Abuse of OC decreased 48% in national poison center surveillance systems, decreased 32% in a national drug treatment system, and decreased 27% among individuals prescribed OC in claims databases. Doctor‐shopping for OC decreased 50%. Overdose fatalities reported to the manufacturer decreased 65%. Abuse of other opioids without abuse‐deterrent properties decreased 2 years later than OC and with less magnitude, suggesting OC decreases were not due to broader opioid interventions. Consistent with the formulation, decreases were larger for nonoral than oral abuse. Abuse‐deterrent opioids may mitigate abuse and overdose risks among chronic pain patients.
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影响因子：
4.2
作者：
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通讯作者：
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影响因子：
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