Injectable Double-Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment
Injectable Double-Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment
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具有高机械弹性和有效能量耗散的可注射双交联粘合水凝胶用于关节伤口治疗
DOI：
10.1002/adfm.202109687
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发表时间：
2021-12-01
影响因子：
19
通讯作者：
Liu, Changsheng
中科院分区：
文献类型：
--
作者：
Chen, Kai;Wu, Zihan;Liu, Changsheng
由于潮湿的环境和不可避免的运动，有效的伤口闭合和脆弱关节皮肤的愈合仍然是一个巨大的挑战。本文报道了一种聚（γ-谷氨酸）交联的氨基功能化聚乙二醇化聚（甘油癸二酸酯）（γ-PGA/PEGS-NH2）粘合水凝胶。 PEGS-NH2和γ-PGA不仅与生物组织表面形成共价酰胺键以实现强湿粘附，而且在块体水凝胶中建立稳定的化学交联网络以抵抗变形。此外，引入仿生没食子酸改性壳聚糖（CS-GA），通过多个氢键增强湿粘附性，并建立动态物理交联网络以耗散能量。因此，这种粘性水凝胶可以牢固地粘附在潮湿的生物组织上，其粘附力比纤维蛋白胶高六倍，与强氰基丙烯酸酯胶相当。此外，得益于高机械弹性和有效的能量耗散，在粘合状态下进行的200次循环加载-卸载力学测试以及应用于动态颈背的全层大鼠皮肤切口模型进一步证实了理想的动态组织粘合和伤口愈合性能。将上述理想特征与其良好的可注射性和对复杂轮廓的形状适应性相结合，这种粘合水凝胶被证明是在潮湿和动态的生理环境中关节伤口闭合和愈合的有希望的候选者。
Due to the moist environment and inevitable movement, efficient wound closure and healing of vulnerable joint skin remains a great challenge. Herein, a poly(gamma-glutamic acid)-crosslinked amino-functionalized PEGylated poly(glycerol sebacate) (gamma-PGA/PEGS-NH2) adhesive hydrogel is reported. PEGS-NH2 and gamma-PGA not only forms covalent amide bonds with biological tissue surfaces to achieve strong moist adhesion but also establishes a stable chemically crosslinked network in bulk hydrogels to resist deformation. Furthermore, bioinspired gallic acid-modified chitosan (CS-GA) is introduced to enhance moist adhesion via multiple hydrogen bonds and establish a dynamic physically crosslinked network to dissipate energy. Consequently, this adhesive hydrogel strongly adheres to moist biological tissue, showing an adhesion six times higher than that of fibrin glue and comparable to that of strong cyanoacrylate glue. Moreover, benefiting from high mechanical resilience and effective energy dissipation, 200 cycles of loading-unloading mechanical tests conducted under an adhesive state and a full-thickness rat skin incision model applied on a dynamic nape further confirmed the desirable dynamic tissue adhesion and wound healing performance. Combining the above ideal features with their good injectability and shape-adaptability to complex contours, such adhesive hydrogels are demonstrated to be promising candidates for joint wound closure and healing in moist and dynamic physiological environment.