Natural killer T cells in liver injury, inflammation and cancer.
Natural killer T cells in liver injury, inflammation and cancer.
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自然杀伤 T 细胞在肝损伤、炎症和癌症中的作用
DOI：
10.1586/17474124.2015.1056738
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yin Shi
中科院分区：
文献类型：
--
作者：
Wang Hua;Yin Shi
肝脏是自然杀伤T（NKT）细胞数量最多的器官，其在肝脏疾病的发病机制中起关键作用。本文就NKT细胞在肝损伤、炎症、纤维化、再生和肿瘤中的作用作一综述。简而言之，NKT细胞通过产生促炎细胞因子和直接杀死肝细胞来加速肝损伤。NKT细胞在肝纤维化发生中起着复杂的作用。例如，NKT细胞通过抑制肝星状细胞活化来抑制肝纤维化，并且还可以通过增强肝脏炎症和损伤来促进肝纤维化。失活或弱活化的NKT细胞在控制肝再生中起最小作用，而活化的NKT细胞对肝再生具有抑制作用。在肝癌中，NKT细胞在控制肿瘤进展方面发挥促肿瘤和抗肿瘤作用。
The liver is an organ that has the largest amount of natural killer T(NKT) cells, which play critical roles in the pathogenesis of liver diseases. In this article, the authors summarize recent findings about the roles of NKT cells in liver injury, inflammation, fibrosis, regeneration and cancer. In brief, NKT cells accelerate liver injury by producing pro-inflammatory cytokines and directly killing hepatocytes. NKT cells are involved in complex roles in liver fibrogenesis. For instance, NKT cells inhibit liver fibrosis via suppressing hepatic stellate cell activation and can also promote liver fibrosis via enhancing liver inflammation and injury. Inactivated or weakly activated NKT cells play a minimal role in controlling liver regeneration, whilst activated NKT cells have an inhibitory effect on liver regeneration. In liver cancer, NKT cells play both pro-tumor and anti-tumor roles in controlling tumor progress.