BIOPHYSICAL CHARACTERIZATION OF ROTAVIRUS PARTICLES CONTAINING REARRANGED GENOMES
BIOPHYSICAL CHARACTERIZATION OF ROTAVIRUS PARTICLES CONTAINING REARRANGED GENOMES
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DOI：
10.1099/0022-1317-68-11-2961
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发表时间：
1987-11-01
影响因子：
3.8
通讯作者：
DESSELBERGER, U
中科院分区：
文献类型：
--
作者：
MCINTYRE, M;ROSENBAUM, V;DESSELBERGER, U
发现含有重排基因组的人类轮状病毒在病毒颗粒中包装多达1800个额外的碱基对。所比较的病毒在它们的颗粒直径和它们的表观S值方面是不可区分的。发现含有重排基因组的颗粒比含有标准基因组的轮状病毒颗粒具有更高的密度，如通过平衡密度超离心测定的。密度的增加与额外包装的碱基对的数量成正比。
Human rotaviruses containing rearranged genomes were found to package up to 1800 additional base pairs in virus particles. The viruses compared were indistinguishable in respect of their particle diameters and their apparent S values. Particles containing rearranged genomes were found to be of a higher density than rotavirus particles containing a standard genome as determined by equilibrium density ultracentrifugation. The increase in density was directly proportional to the number of additionally packaged base pairs.