Leukemic cell and plasma daunomycin concentrations after bolus injection and 72 h infusion
Leukemic cell and plasma daunomycin concentrations after bolus injection and 72 h infusion
复制标题
推注和输注 72 小时后白血病细胞和血浆道诺霉素浓度
DOI：
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发表时间：
2004
影响因子：
3
通讯作者：
C. Haanen
中科院分区：
文献类型：
--
作者：
P. Speth;P. Linssen;J. Boezeman;H. Wessels;C. Haanen
SummaryThe effect of the duration of daunomycin (DNM) infusion on leukemic cell drug concentrations was evaluated. Cellular and plasma DNM concentrations were measured in 20 patients with acute non-lymphocytic leukemia. DNM 45 mg/m2 was administered either as a bolus injection or as a 4-, 8- or 72-h constant-rate infusion during 3 consecutive days. Peak plasma DNM levels amounted to 227±116 ng/ml after bolus injection and were only 16±6 ng/ml after 72-h DNM infusions. Terminal plasma DNM half-lives were 14±4 h. Peak leukemic cell DNM concentrations at the 3rd day of administration were 16810±2580 ng/109 cells (bolus injections) and 10310±5510 ng/109 cells (72-h infusions). The areas under the cellular curve were similar and independent of the duration of the DNM infusion. Peak leukemic cell daunomycinol (DNMol) concentrations were respectively 3500 ± 1600 ng/109 cells and 2850±1720 ng/109 cells. Cellular DNM terminal half-life was 13±4 h. DNM concentrations in nucleated blood and bone marrow cells correlated well (r=0.93, n=26). Long-term infusion produced less severe side effects. Therapeutic efficacy was maintained during long-term infusion.
柔红霉素治疗成人急性非淋巴细胞白血病的精选研究。
影响因子：
4
作者：
Wiernik,PH
通讯作者：
Wiernik,PH