Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches.
Ion channel remodeling in vascular smooth muscle during hypertension: Implications for novel therapeutic approaches.
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DOI：
10.1016/j.phrs.2013.01.008
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发表时间：
2013-04
影响因子：
9.3
通讯作者：
Rhee, Sung W.
中科院分区：
文献类型：
--
作者：
Joseph, Biny K.;Thakali, Keshari M.;Moore, Christopher L.;Rhee, Sung W.
离子通道是多聚体的跨膜蛋白，在包括血管平滑肌细胞（VSMC）在内的多种细胞中，有选择地介导跨质膜的离子通量。 VSMC质膜上Ca2+和K+通道的动态相互作用在调节小动脉和动脉的血管张力方面起着关键作用。在高血压中观察到的异常高度的动脉张力表明VSMC中Ca2+和K+通道的异常表达和功能。在这篇简短的综述中，我们关注VSMC中的三个经过良好的离子通道，即L型Ca2+（CAV1.2）通道，电压门控的K+（KV）通道和大型导电CA2+激活的K+ （BK）频道。首先，我们简要概述了血管CAV1.2，KV和BK通道在调节动脉张力中的生理作用。其次，我们讨论了高血压期间脉管系统中CAV1.2，KV和BK通道的表达变化和调节的当前理解。第三，根据可用的概念验证研究，我们描述了针对这些血管离子通道的潜在治疗方法，以便将血压恢复到正常水平。
Ion channels are multimeric, transmembrane proteins that selectively mediate ion flux across the plasma membrane in a variety of cells including vascular smooth muscle cells (VSMCs). The dynamic interplay of Ca2+ and K+ channels on the plasma membrane of VSMCs plays a pivotal role in modulating the vascular tone of small arteries and arterioles. The abnormally-elevated arterial tone observed in hypertension thus points to an aberrant expression and function of Ca2+ and K+ channels in the VSMCs. In this short review, we focus on the three well-studied ion channels in VSMCs, namely the L-type Ca2+ (CaV1.2) channels, the voltage-gated K+ (KV) channels, and the large-conductance Ca2+-activated K+ (BK) channels. First, we provide a brief overview on the physiological role of vascular CaV1.2, KV and BK channels in regulating arterial tone. Second, we discuss the current understanding of the expression changes and regulation of CaV1.2, KV and BK channels in the vasculature during hypertension. Third, based on available proof-of-concept studies, we describe the potential therapeutic approaches targeting these vascular ion channels in order to restore blood pressure to normotensive levels.
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影响因子：
15.9
作者：
Amberg, GC;Bonev, AD;Santana, LF
通讯作者：
Santana, LF
影响因子：
--
作者：
ASANO, M;MASUZAWAITO, K;ITO, K
通讯作者：
ITO, K
影响因子：
3
作者：
Birnbaumer, L;Qin, N;Stefani, E
通讯作者：
Stefani, E
DOI：
10.1152/ajpheart.01053.2004
发表时间：
2005-09-01
影响因子：
4.8
作者：
Bratz, IN;Swafford, AN;Dick, GM
通讯作者：
Dick, GM
影响因子：
4.8
作者：
Chen, LN;Cagniard, B;Zhuang, XX
通讯作者：
Zhuang, XX