Synovial fluid analysis for diagnosis of intercritical gout
Synovial fluid analysis for diagnosis of intercritical gout
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DOI：
10.7326/0003-4819-131-10-199911160-00007
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发表时间：
1999-11-16
影响因子：
39.2
通讯作者：
Vela, P
中科院分区：
文献类型：
--
作者：
Pascual, E;Batlle-Gualda, E;Vela, P
背景资料：痛风在临界期的诊断可能是困难的。目的：确定滑液分析是否允许诊断临界期痛风。设计：横断面研究。设置：门诊流变学诊所。患者：101例痛风患者。干预：80个膝关节和21个第一跖趾关节的关节穿刺术（来自不同患者的关节）已经发炎，但目前无症状。测量：频率与arthrocentesis产生滑液;滑液样品中存在结晶;和，滑液与晶体，必须扫描晶体前的显微镜视野的数量被发现。结果：滑液从91 101关节。所有43例未接受降尿酸药物治疗的患者的液体均含有尿酸盐晶体。在48名接受降尿酸药物治疗的患者中，仅34名患者的滑液中发现了这些晶体。在90%的滑液样品中含有晶体，晶体被认为是在第一个五个显微镜领域investigated.Conclusions：无症状的膝盖和第一跖趾关节和滑液分析的关节穿刺术是简单的程序，便于诊断痛风在关键时期。
Background: The diagnosis of gout in the intercritical phase can be difficult.Objective: To determine whether synovial fluid analysis allows the diagnosis of intercritical gout.Design: Cross-sectional study.Setting: Outpatient rheumatology clinics.Patients: 101 patients with gout.Intervention: Arthrocentesis of 80 knees and 21 first metatarsophalangeal joints teach joint from a different patient) that had been inflamed but were currently asymptomatic.Measurements: Frequency with which arthrocentesis yielded synovial fluid; presence of monosodium urate crystals in the synovial fluid sample; and, for synovial fluid with crystals, the number of microscope fields that had to be scanned before crystals were found.Results: Synovial fluid was obtained from 91 of 101 joints. The fluid from all 43 patients not receiving hypouricemic agents contained monosodium urate crystals. These crystals were found in the synovial fluid of only 34 of 48 patients receiving hypouricemic agents. In 90% of the synovial fluid samples that contained crystals, crystals were seen in the first five microscope fields examined.Conclusions: Arthrocentesis of asymptomatic knees and first metatarsophalangeal joints and synovial fluid analysis are simple procedures that facilitate the diagnosis of gout during intercritical periods.