A concise construction of 4-alkynylquinazolines via [4 2] annulation of 4-alkynylbenzoxazinanones with acylhydroxamates under transition-metal-free conditions
A concise construction of 4-alkynylquinazolines via [4 2] annulation of 4-alkynylbenzoxazinanones with acylhydroxamates under transition-metal-free conditions
复制标题
在无过渡金属条件下，通过 4-炔基苯并恶嗪酮与酰基异羟肟酸酯的 [4 2] 环化，简明构建 4-炔基喹唑啉
DOI：
10.1039/c9qo00668k
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发表时间：
2019
影响因子：
5.4
通讯作者：
Li Ming
中科院分区：
文献类型：
--
作者：
Yuan Wen Kui;Sun Sheng Zheng;Zhang Lin Bao;Wen Li Rong;Li Ming
A concise and highly efficient method for the construction of valuable 4-alkynylquinazolines under transition-metal-free conditions was developed via [4 + 2] annulation of 4-alkynylbenzoxazinanones with acylhydroxamates in good to excellent yields. The reaction featured the use of low-cost bases NaOAc or NaOMe, simple operation and high chemoselectivity. The broad substrate scope and the typical maintenance of high efficiency on a gram scale made this protocol a potentially practical method to synthesize 4-alkynylquinazolines.
