Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness
Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness
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DOI：
10.1016/j.braindev.2008.07.010
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发表时间：
2009-06-01
影响因子：
1.7
通讯作者：
Watanabe, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Hirabayashi, Yu;Okumura, Akihisa;Watanabe, Kazuyoshi
Purpose: To assess the efficacy of diazepam suppositories at preventing febrile seizure recurrence during a single febrile illness to determine how to treat children with a febrile seizure on presentation at the hospital. Methods: We studied 203 children with febrile seizures from December 2004 through March 2006. On admission between December 2004 and May 2005, a diazepam suppository was administered to the patients. Patients seen between June 2005 and March 2006 were not treated with antiepileptic drugs on admission. Results: We saw a significant difference in the rate of recurrence of febrile seizures between children treated with diazepam and those who were not. Recurrences were observed in 2 (2.1%) of 95 children treated with diazepam and in 16 (14.8%) of 108 untreated children. For the 108 untreated patients, the median age was 22.8 months in those with recurrences and 30.6 months in those without, confirming that a younger age was related to a recurrence. Conclusions: A diazepam suppository after a febrile seizure will reduce the incidence of recurrent febrile seizures during the same febrile illness. However, a diazepam suppository after a febrile seizure should be used after carefully considering the benefits and potential adverse effects. (C) 2008 Elsevier B.V. All rights reserved.
