Sex-specific differences in adrenocortical attunement in mothers with a history of childhood abuse and their 5-month-old boys and girls
Sex-specific differences in adrenocortical attunement in mothers with a history of childhood abuse and their 5-month-old boys and girls
复制标题
DOI：
10.1007/s00702-016-1525-6
复制
发表时间：
2016-09-01
影响因子：
3.3
通讯作者：
Kaess, M.
中科院分区：
文献类型：
--
作者：
Fuchs, Anna;Moehler, E.;Kaess, M.
最近的证据表明母亲和孩子之间存在神经生物学调谐，例如，母亲和孩子下丘脑-垂体-肾上腺（HPA）轴功能之间的关联。由于母亲虐待史（HoA）已被证明会对母子互动和hpa轴功能产生负面影响，我们将这些经历理论化，以对皮质醇调节产生影响，并研究了婴儿性别在这一背景下的作用。在她们的第一个孩子出生后不久，一个社区的妇女样本使用童年创伤问卷进行筛选。报告中度或重度性虐待和/或身体虐待的母亲被纳入虐待组（n = 41； MG），并与未遭受虐待的对照组（n = 47； CG）进行比较。在孩子5个月大时，在11点至1点之间连续两天收集母亲和婴儿的基线唾液皮质醇。相关分析证实了母亲和婴儿唾液皮质醇水平之间的关联。然而，层次回归模型揭示了母亲HoA和婴儿性别的调节作用：在CG中，皮质醇调节仅在母女二代中显着，而在MG中，我们发现皮质醇水平仅在母子二代中相关。因此，母亲和孩子之间神经生物学调谐的改变可能构成不良童年经历跨代传递的机制。
Recent evidence points to the existence of a neurobiological attunement between mother and child, e.g., associations between maternal and child hypothalamic-pituitary-adrenal (HPA) axis functioning. As maternal history of abuse (HoA) has been shown to negatively affect mother-child interaction and HPA-axis functioning, we theorized those experiences to exert an influence on cortisol attunement, and we examined the role of infant gender in this context. Shortly after birth of their first child, a community sample of women was screened using the Childhood Trauma Questionnaire. Mothers reporting moderate or severe sexual and/or physical abuse were included in the maltreatment group (n = 41; MG) and compared with a non-maltreated comparison group (n = 47; CG). At the child's age of 5 months, mother and infant baseline salivary cortisol was collected on two consecutive days between 11 and 1 o'clock. Correlation analyses confirmed an association between maternal and infant salivary cortisol levels for the complete sample. However, hierarchical regression models revealed a moderating role of maternal HoA and infant gender: in the CG, cortisol attunement was only significant in mother-daughter dyads, whereas in the MG, we found cortisol levels to be associated only in mother-son dyads. Consequently, alterations of neurobiological attunement between mother and child might compose a mechanism for the transgenerational transmission of adverse childhood experiences.