Distribution of Experimentally Induced Scrapie Lesions in the Brain

Distribution of Experimentally Induced Scrapie Lesions in the Brain
复制标题

实验诱发的瘙痒病病变在大脑中的分布

DOI：
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发表时间：
1967
期刊：
Nature
影响因子：
64.8
通讯作者：
A. Dickinson
A. Dickinson
中科院分区：
综合性期刊1区
文献类型：
--
作者：
H. Fraser;A. Dickinson

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被引文献

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痒病的病变仅限于中枢神经系统。山羊中使用的两种瘙痒病剂菌株1以及因给小鼠注射煮沸和未煮沸的材料而产生的病变2描述了这些病变分布的差异。我们还收集了未发表的数据，显示由于在小鼠中使用不同菌株的药物或通过用相同的药物接种不同基因型的小鼠而导致的病变分布存在很大差异。
LESIONS of scrapie are confined to the central nervous system. Differences in the distribution of these lesions have been described for the two strains of scrapie agent used in goats1 and for the lesions which arise as a result of injecting mice with boiled and unboiled material2. We have also collected unpublished data showing wide variation in the distribution of lesions which result from using different strains of the agent in mice or by inoculating, different genotypes of mice with the same agent.