Tumor response to thermoradiation therapy: use of CT in evaluation.
Tumor response to thermoradiation therapy: use of CT in evaluation.
复制标题
肿瘤对热放射治疗的反应：使用 CT 进行评估。
DOI：
10.1148/radiology.164.1.3588915
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发表时间：
1987
期刊：
影响因子：
19.7
通讯作者：
M. Abe
中科院分区：
文献类型：
--
作者：
M. Hiraoka;K. Akuta;Y. Nishimura;Y. Nagata;S. Jo;M. Takahashi;M. Abe
在热放射治疗前后，通过计算机断层扫描 (CT) 对 72 个肿瘤（大部分位于深部位置）进行了回顾性研究。照射后（总剂量20-70.2Gy）用射频电容加热设备进行局部热疗，每次40-60分钟，总共4至13次。 72 个肿瘤中有 16 个显示出完全消退。肿瘤消退与平均最高或最低肿瘤温度无关。热放射治疗后获得的 CT 扫描显示，56 个肿瘤中有 32 个肿瘤存在明显的低密度区域，但并未完全消退。对 32 个肿瘤中的 14 个进行组织病理学检查，结果显示低密度区域为大量凝固性坏死。低密度区根据其在肿瘤中所占面积的百分比分为三型：3型（大于80%）、2型（50%-80%）和1型（小于50%）。该类型与平均最高和最低肿瘤温度相关，随访观察和组织病理学检查显示对大多数3型肿瘤有很大影响。
Seventy-two tumors, mostly in deep locations, were studied retrospectively with computed tomography (CT) before and after thermoradiation therapy. Hyperthermia was administered locally or regionally with radio frequency capacitive heating equipment after irradiation (total dose, 20-70.2 Gy) for 40-60 minutes per session in a total of four to 13 sessions. Sixteen of the 72 tumors showed complete regression. Tumor regression was not related to the average maximum or minimum tumor temperature. CT scans obtained after thermoradiation therapy demonstrated a clear low-density area in 32 of 56 tumors that did not regress completely. Histopathologic examinations, performed in 14 of the 32 tumors, showed the low-density area to be massive coagulation necrosis. The low-density area was classified into three types according to its percentage area in the tumor: type 3 (more than 80%), type 2 (50%-80%), and type 1 (less than 50%). The type correlated with the average maximum and minimum tumor temperature, and follow-up observations and histopathologic examinations showed great effects in most of the type 3 tumors.