Diagnosis and Management of Graves' Ophthalmopathy
Diagnosis and Management of Graves' Ophthalmopathy
复制标题
格雷夫斯眼病的诊断和治疗
DOI：
10.1210/jcem-71-3-559
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
C. Gorman
中科院分区：
文献类型：
--
作者：
R. Bahn;J. Garrity;C. Gorman
格雷夫斯眼病是一种潜在的视力威胁和毁容疾病。25-50%的Graves'甲亢患者存在轻微或明显的眼病临床证据。然而，敏感的成像技术，如眼眶超声检查和计算机断层扫描显示，在绝大多数甲亢患者的眼部参与的证据。相反，对甲状腺功能明显正常的Graves眼病患者的仔细研究表明，超过70%的患者目前患有或最终将发展为轻微或明显的甲状腺功能障碍。目前，还没有预防Graves眼病的方法，对确诊的、有症状的疾病的治疗也只是治标不治本。格雷夫斯眼病患者常主诉眼部异物感、流泪、畏光、视力模糊、复视或眶深压。典型的检查结果包括眶周和眼睑水肿，眼睑退缩，眼睑下垂，结膜炎。
Graves' ophthalmopathy is a potentially sight-threatening and disfiguring disease. Subtle or overt clinical evidence of ophthalmopathy is present in 25–50% of patients with Graves' hyperthyroidism. However, sensitive imaging techniques such as orbital ultrasonography and computerized tomography have demonstrated evidence of ocular involvement in the vast majority of hyperthyroid patients. Conversely, careful study of apparently euthyroid patients with Graves' ophthalmopathy indicates that greater than 70% either presently have, or will eventually develop, subtle or overt thyroid dysfunction. At the present time, there are no means to prevent Graves' ophthalmopathy and treatment for established, symptomatic disease is only palliative. Patients with Graves' ophthalmopathy frequently complain of an ocular foreign body sensation, lacrimation, photophobia, blurring of vision, double vision, or deep orbital pressure. Typical findings on examination include periorbital and lid edema, lid retraction, lid lag, con...