Serotonin transporter polymorphism predicts waking cortisol in young girls
Serotonin transporter polymorphism predicts waking cortisol in young girls
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DOI：
10.1016/j.psyneuen.2008.11.006
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发表时间：
2009-06-01
影响因子：
3.7
通讯作者：
Gotlib, Ian H.
中科院分区：
文献类型：
--
作者：
Chen, Michael C.;Joormann, Jutta;Gotlib, Ian H.
严重抑郁障碍(MDD)是所有精神疾病中最普遍、最昂贵的疾病之一。下丘脑-垂体-肾上腺(HPA)轴调节荷尔蒙对压力的反应，已被发现在抑郁症中被破坏。HPA失调可能是抑郁症的一个重要危险因素。为了在不混淆当前或终生抑郁症的情况下检查这一危险因素的可能遗传基础，我们对84名从未患抑郁症的年轻女孩进行了基因分型，其中超过三分之一的女孩患抑郁症的风险增加，以评估5-HTT基因启动子区的多态与HPA轴活动的日变化之间的关联。这个5-HTT连锁的多态区域(5-HTTLPR)此前已被发现与压力相互作用，增加患抑郁症的风险。我们发现5-HTTLPR与白天的皮质醇水平显著相关：短等位基因纯合的女孩比长等位基因的女孩有更高的清醒皮质醇水平(但不是下午或晚上)。这一发现表明，对HPA轴失调的遗传易感性，特别是在醒着的皮质醇水平上，可以在年仅9岁的个体中检测到。(C)2008爱思唯尔有限公司。保留所有权利。
Major Depressive Disorder (MDD) is one of the most prevalent and costly of all psychiatric disorders. The hypothalamic pituitary adrenal (HPA)-axis, which regulates the hormonal response to stress, has been found to be disrupted in depression. HPA dysregulation may represent an important risk factor for depression. To examine a possible genetic underpinning of this risk factor without the confound of current or lifetime depression, we genotyped 84 never-disordered young girls, over a third of whom were at elevated risk for depression, to assess the association between a polymorphism in the promoter region of the serotonin transporter (5-HTT) gene and diurnal variation in HPA-axis activity. This 5-HTT-linked polymorphic region (5-HTTLPR) has been previously found to interact with stress to increase risk for depression. We found 5-HTTLPR to be significantly associated with diurnal cortisol levels: girls who were homozygous for the short-allele had higher levels of waking (but not afternoon or evening) cortisol than did their long-allele counterparts. This finding suggests that genetic susceptibility to HPA-axis dysregulation, especially apparent in levels of waking cortisol, is detectable in individuals as young as 9 years of age. (C) 2008 Elsevier Ltd. All rights reserved.