Reduced exercise capacity in persons with Down syndrome: cause, effect, and management.
Reduced exercise capacity in persons with Down syndrome: cause, effect, and management.
复制标题
唐氏综合症患者的运动能力降低：原因，效果和管理。
DOI：
10.2147/tcrm.s10235
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发表时间：
2010-12-08
影响因子：
2.8
通讯作者：
Fernhall B
中科院分区：
文献类型：
--
作者：
Mendonca GV;Pereira FD;Fernhall B
唐氏综合征（DS）患者的峰值和次最大运动能力降低。由于运动能力是成年DS患者生存的预测因素之一，因此对这些个体运动能力降低的原因、影响和管理的现有知识进行回顾是很重要的。现有数据表明，DS患者的运动能力降低是由于低峰值摄氧量（VO2peak）和运动经济性差之间的相互作用。在几种可能的解释中，变时性功能不全已被证明是DS中低VO2峰值的主要原因。相反，差的运动经济性显然取决于关节松弛和肌肉张力减退导致的步态动力学和运动学紊乱。重要的是，有足够的证据表明，这种低水平的身体健康（运动能力和肌肉力量降低）限制了DS成年人执行日常生活功能任务的能力。因此，临床管理减少运动能力的DS似乎很重要，以确保这些人保持生产力和健康的整个生命。然而，很少有前瞻性研究探讨了结构化运动训练对这一人群的影响。有证据表明，运动训练有利于改善DS患者的运动能力和生理功能。本文综述了目前的知识的原因，影响和管理减少运动能力的DS。本次审查是有限的急性和慢性次最大和峰值运动强度的反应，因为数据的人与DS的超大运动能力已被证明是不可靠的。
Persons with Down syndrome (DS) have reduced peak and submaximal exercise capacity. Because ambulation is one predictor of survival among adults with DS, a review of the current knowledge of the causes, effects, and management of reduced exercise capacity in these individuals would be important. Available data suggest that reduced exercise capacity in persons with DS results from an interaction between low peak oxygen uptake (VO2peak) and poor exercise economy. Of several possible explanations, chronotropic incompetence has been shown to be the primary cause of low VO2peak in DS. In contrast, poor exercise economy is apparently dependent on disturbed gait kinetics and kinematics resulting from joint laxity and muscle hypotonia. Importantly, there is enough evidence to suggest that such low levels of physical fitness (reduced exercise capacity and muscle strength) limit the ability of adults with DS to perform functional tasks of daily living. Consequently, clinical management of reduced exercise capacity in DS seems important to ensure that these individuals remain productive and healthy throughout their lives. However, few prospective studies have examined the effects of structured exercise training in this population. Existent data suggest that exercise training is beneficial for improving exercise capacity and physiological function in persons with DS. This article reviews the current knowledge of the causes, effects, and management of reduced exercise capacity in DS. This review is limited to the acute and chronic responses to submaximal and peak exercise intensities because data on supramaximal exercise capacity of persons with DS have been shown to be unreliable.