Antimicrobial ambiguines from the cyanobacterium Fischerella sp. collected in Israel
Antimicrobial ambiguines from the cyanobacterium Fischerella sp. collected in Israel
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DOI：
10.1021/np060495r
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发表时间：
2007-02-01
影响因子：
5.1
通讯作者：
Carmeli, Shmuel
中科院分区：
文献类型：
--
作者：
Raveh, Avi;Carmeli, Shmuel
以生物测定法为指导，对培养的费氏蓝藻菌株的MeOH/水提取物进行了7:3的分离，得到了9种含异腈的生物碱。其中三种化合物为新化合物，分别为歧义H异腈(1)、歧义I异腈(2)和歧义J异腈(3)，而其他六种化合物为12-外hapalindole H、歧义A异腈、歧义B异腈、歧义D异腈、歧义E异腈和歧义F异腈，均为先前从Fischerella ambigua中分离得到的化合物。化合物的结构通过一维和二维核磁共振技术和质谱数据确定。歧义H异丁腈和歧义I异丁腈具有抗菌和抗真菌活性。
Bioassay-guided fractionation of the 7:3 MeOH/water extract of a cultured cyanobacterium strain identified as Fischerella sp. yielded nine isonitrile-containing alkaloids. Three of the compounds, ambiguine H isonitrile (1), ambiguine I isonitrile (2), and ambiguine J isonitrile (3), are new, while the other six, 12-epi-hapalindole H, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, and ambiguine F isonitrile, have been previously isolated from Fischerella ambigua. The structures of the compounds were determined by 1D and 2D NMR techniques and mass spectrometric data. Ambiguine H isonirile and ambiguine I isonirile possess antibacterial and antimycotic activity.