Evaluation of Protein S-100 serum concentrations in healthy newborns and seven newborns with perinatal acidosis
Evaluation of Protein S-100 serum concentrations in healthy newborns and seven newborns with perinatal acidosis
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DOI：
10.1080/080352500750027844
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发表时间：
2000-05-01
期刊：
影响因子：
3.8
通讯作者：
Speer, CP
中科院分区：
文献类型：
--
作者：
Maschmann, J;Erb, MA;Speer, CP
对66例出生1周内的健康新生儿和7例围产期酸中毒的新生儿血清S蛋白进行了检测。正常范围为0.66~3.33mg/L(2.5%~97.5%)。结论：围产期酸中毒后有缺氧缺血性脑病体征的新生儿血清蛋白S-100水平升高，而无上述体征的新生儿血清蛋白水平正常。因此，S-100可能是新生儿中枢神经系统损伤的一个标志物。
We measured Protein S-100 serum levels in 66 healthy newborns during the first week of life and in 7 newborns with perinatal acidosis. Normal values (n = 66) constantly ranged between 0.66 and 3.33 mu g/l (2.5 and 97.5 percentiles) during the evaluation period.Conclusions: Newborns with signs of hypoxic-ischaemic encephalopathy (HIE) after perinatal acidosis showed elevated Protein S-100 serum levels, whereas newborns without these signs had normal concentrations. S-100 might thus be a marker of central nervous system damage in newborns.