The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis.
The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis.
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线粒体 DNA 拷贝数改变与癌症风险之间的关系：荟萃分析
DOI：
10.1038/srep10039
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发表时间：
2015-05-08
影响因子：
4.6
通讯作者：
Wang B
中科院分区：
文献类型：
--
作者：
Mi J;Tian G;Liu S;Li X;Ni T;Zhang L;Wang B
Currently, a comprehensive assessment between mitochondrial DNA (mtDNA) content and cancer risk is lacking. We designed this meta-analysis to test the hypothesis that altered mtDNA copy number might influence genetic susceptibility to some specific types of cancer. The processes of literature search, eligibility appraisal and data retrieval were independently completed in duplicate. The mtDNA copy number which was dichotomized or classified into tertiles was compared between cancer cases and controls. Twenty-six articles with 38 study groups were analyzed among 6682 cases and 9923 controls. When dichotomizing mtDNA copy number at the median value, there was an 11% increased cancer risk for carriers of high mtDNA content (P = 0.320). By cancer type, high mtDNA content was associated with an increased risk for lymphoma (OR = 1.76; P = 0.023) but a reduced risk for skeleton cancer (OR = 0.39; P = 0.001). Carriers of the 2nd and 3rd tertiles of mtDNA copy number had an 1.74-fold (P = 0.010) and 2.07-fold (P = 0.021) increased risk of lymphoma, respectively. By contrast, there was correspondingly a 56% (P < 0.001) and 80% (P < 0.001) reduced risk of skeleton cancer. Our findings suggested that elevated mtDNA content was associated with a higher risk for lymphoma, but a lower risk for skeleton cancer.
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影响因子：
5.3
作者：
Figueroa, Jonine D.;Malats, Nuria;Garcia-Closas, Montserrat
通讯作者：
Garcia-Closas, Montserrat
影响因子：
4.7
作者：
Ito, H;Matsuo, K;Tajima, K
通讯作者：
Tajima, K
影响因子：
3.1
作者：
Mitra, Amit Kumar;Singh, Neetu;Rath, Srikanta Kumar
通讯作者：
Rath, Srikanta Kumar
DOI：
10.1016/j.mrgentox.2007.03.010
发表时间：
2007-07-28
影响因子：
1.9
作者：
De Ruyck, Kim;Szaumkessel, Marcin;Thierens, Hubert
通讯作者：
Thierens, Hubert
影响因子：
6.6
作者：
Chen, L;Ambrosone, CB;Park, JY
通讯作者：
Park, JY