Stem cells: current challenges and future promise.
Stem cells: current challenges and future promise.
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干细胞：当前的挑战和未来的希望。
DOI：
10.1002/dvdy.21203
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Battey,JamesF
中科院分区：
文献类型：
--
作者：
Battey,JamesF
干细胞有两个显着的特性。它们可以自我更新，也可以分化成一种或多种成体细胞类型。来自人类胚胎的干细胞在细胞培养中似乎具有无限的自我更新能力，并且它们还能够分化成数百种成体细胞类型。人类胚胎干细胞系提供了一种平台技术，有可能阐明决定成体细胞命运的分子机制，生成用于发现新药物的细胞模型，并为新型移植疗法创建分化细胞群。美国国立卫生研究院 (NIH) 已经确定了实现这一潜力的一些限制步骤，并制定了资助计划来加速研究进展。鉴于干细胞的巨大潜力，美国国立卫生研究院对干细胞研究的支持是可预见的未来的一个重要优先事项。发展动力学 236:3193–3198, 2007。2007 年出版 Wiley‐Liss, Inc.
Stem cells have two remarkable properties. They can either renew themselves or they can differentiate into one or more adult cell types. Stem cells derived from a human embryo appear to have an unlimited capacity to self‐renew in cell culture, and they are also able to differentiate into hundreds of adult cell types. Human embryonic stem cell lines offer a platform technology that has the potential to elucidate the molecular mechanisms that determine adult cell fate, generate cellular models for discovery of new drugs, and create populations of differentiated cells for novel transplantation therapies. The National Institutes of Health (NIH) has identified some of the rate‐limiting steps toward realizing this potential, and has forged funding initiatives to accelerate research progress. Given the remarkable potential, NIH support for research using stem cells is an important priority for the foreseeable future. Developmental Dynamics 236:3193–3198, 2007. Published 2007 Wiley‐Liss, Inc.