Effect of atrial natriuretic peptide on gonadotropin release in superfused rat pituitary cells.
Effect of atrial natriuretic peptide on gonadotropin release in superfused rat pituitary cells.
复制标题
心钠素对灌注大鼠垂体细胞促性腺激素释放的影响。
DOI：
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发表时间：
1986
影响因子：
11.1
通讯作者：
A. Schally
中科院分区：
文献类型：
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作者：
J. Horváth;T. Ertl;A. Schally
心脏心房肌细胞产生一种多肽激素，在控制水和电解质平衡和血压方面发挥作用。这种激素的循环形式是心钠素(ANP)，它含有28个氨基酸。各种免疫组织化学研究表明，ANP存在于中枢神经系统的许多区域，包括正中隆起。在我们的研究中，我们研究了ANP在超融合大鼠垂体细胞系统中的作用。当ANP浓度增加(0.01微米至1微米)时，对黄体生成素(LH)和卵泡刺激素(FSH)的释放有明显的剂量相关刺激作用。心钠素在我们系统中的最低有效剂量为0.03微米。ANP和促黄体生成素联合应用时，反应延长，具有ANP刺激的促黄体生成素和卵泡刺激素释放的特点。与以前的一些报道不同的是，高浓度(1微米)的ANP持续诱导少量但显著的促肾上腺皮质激素释放。ANP不影响催乳素、生长激素和促甲状腺激素的基础释放。
Cardiac atrial muscle cells produce a polypeptide hormone that plays a role in the control of water and electrolyte balance and blood pressure. The circulating form of this hormone is the atrial natriuretic peptide (ANP), which contains 28 amino acids. Various immunohistochemical studies have shown that ANP is present in many areas of the central nervous system, including the median eminence. In our studies, we investigated the effect of ANP in a superfused rat pituitary cell system. When ANP was administered at increasing concentrations (0.01 microM to 1 microM), it caused a significant dose-related stimulation of the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The lowest effective dose of ANP in our system was 0.03 microM. When ANP and LH-releasing hormone were administered together, the response was prolonged and had the characteristics of ANP-stimulated LH and FSH release. In contrast with some previous reports, ANP in high concentration (1 microM) consistently induced a small but significant stimulation of the release of corticotropin. ANP did not influence the basal release of prolactin, growth hormone, and thyrotropin.