Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata
Cytotoxic p-Terphenyls from the Endolichenic Fungus Floricola striata
复制标题
来自内生真菌 Floricola striata 的细胞毒性对三联苯
DOI：
10.1021/acs.jnatprod.8b00362
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发表时间：
2018-09-01
影响因子：
5.1
通讯作者：
Lou, Hong-Xiang
中科院分区：
文献类型：
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作者：
Xu, Ke;Gao, Yun;Lou, Hong-Xiang
Eleven new p-terphenyls, floricolins K-U (1-11), together with 13 biosynthetically related known compounds (12-24) were isolated from an endolichenic fungus, Floricola striata. Their structures were elucidated by extensive spectroscopic analyses and single-crystal X-ray diffraction measurements. The newly isolated p-terphenyls inhibited the growth of A2780, MCF-7, and A549 cell lines. Further evaluation for the multidrug resistance (MDR) reversal activity of compound 5 revealed it enhanced the sensitivity of MCF-7/ADR cells toward adriamycin 39-fold at 10 mu M through modulating P-glycoprotein-mediated drug exclusion.
