Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes Mellitus
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with type 2 diabetes Mellitus
复制标题
正常受试者和新诊断 2 型糖尿病患者的循环 FGF-21 水平
DOI：
10.1055/s-2007-985148
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发表时间：
2008-01-01
影响因子：
1.8
通讯作者：
Boden, G.
中科院分区：
文献类型：
--
作者：
Chen, W. -W.;Li, L.;Boden, G.
成纤维细胞生长因子（FGF-21）是近年来发现的一种代谢调节因子。其在人类中的病理生理作用仍然未知。在这项研究中，我们调查了血浆FGF-21水平是否在2型糖尿病（T2 DM）患者和非糖尿病对照组之间存在差异。我们还评估了血浆FGF-21身体组成和几个代谢参数之间的关联。与对照组相比，T2 DM患者的空腹FGF-21水平显著升高（1.82 +/- 0.65 vs. 1.53 +/- 0.60 μ g/L，P
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains unknown. In this study, we have investigated whether or not plasma FGF-21 level was different in patients with type 2 diabetes mellitus (T2DM) and nondiabetic controls. We also assessed associations between plasma FGF-21 body composition and several metabolic parameters. Fasting FGF-21 levels were significantly increased in patients with T2DM compared with controls (1.82 +/- 0.65 vs. 1.53 +/- 0.60 mu g/L, P